GV-58 |CAS:1402821-41-3 Probechem Biochemicals

Chemical Structure : GV-58

CAS No.: 1402821-41-3

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GV-58 (GV58)

货号: PC-43065Not For Human Use, Lab Use Only.

GV-58 is a potent, selective N-Type and P/Q-type Ca2+ Channel agonist with EC50 of 7.2 and 8.8 uM, shows no acitivity for L-type calcium channels (EC50>100 uM).

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5 mg	￥2400	In stock
25 mg	￥5800	In stock
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250 mg		Get quote

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生物&药学活性

GV-58 is a potent, selective N-Type and P/Q-type Ca2+ Channel agonist with EC50 of 7.2 and 8.8 uM, shows no acitivity for L-type calcium channels (EC50>100 uM); has 20-fold less potent cyclin-dependent kinase antagonist effect; slows deactivation (closing) of the channel, resulting in a large increase in total calcium entry during motor nerve action potential activity; weakens Lambert-Eaton myasthenic syndrome-model neuromuscular synapses in a passive transfer mouse model of Lambert-Eaton myasthenic syndrome.

物理化学性质&存储条件

分子量	374.5036
分子式	C18H26N6OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Butanol, 2-[[6-[[(5-methyl-2-thienyl)methyl]amino]-9-propyl-9H-purin-2-yl]amino]-, (2R)-

参考文献

1. Tarr TB, et al. Ann N Y Acad Sci. 2012 Dec;1275:85-91.

2. Tarr TB, et al. J Neurosci. 2013 Jun 19;33(25):10559-67.

3. Tarr TB, et al. J Physiol. 2014 Aug 15;592(16):3687-96.

4. Liang M, et al. ACS Med Chem Lett. 2012 Oct 1;3(12):985-90.

GV-58 (GV58)

生物&药学活性

物理化学性质&存储条件

参考文献

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GV-58 (GV58)

生物&药学活性

物理化学性质&存储条件

参考文献

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