GUT-70 |CAS:161633-75-6 Probechem Biochemicals

Chemical Structure : GUT-70

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GUT-70 (GUT70)

货号: PC-62440Not For Human Use, Lab Use Only.

GUT-70 is a tricyclic coumarin derived from Calophyllum brasiliense, markedly reduces cell proliferation, viability through G1 cell cycle arrest and increases apoptosis.

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生物&药学活性

GUT-70 is a tricyclic coumarin derived from Calophyllum brasiliense, markedly reduces cell proliferation, viability through G1 cell cycle arrest and increases apoptosis; shows binding affinity to heat-shock protein 90 (Hsp90) and ubiquitin-dependent proteasomal degradation of Hsp90 client proteins, including cyclin D1, Raf-1, Akt, and mt-p53; also inhibits HIV-1 replication in both acutely and chronically infected cells through suppression of NF-κB.

物理化学性质&存储条件

分子量	382.456
分子式	C23H26O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2H,8H-Benzo[1,2-b:3,4-b']dipyran-8-one, 5-methoxy-2,2-dimethyl-6-(2-methyl-1-oxo-2-butenyl)-10-propyl-, (E)-

参考文献

1. Kimura S, et al. Int J Cancer. 2005 Jan 1;113(1):158-65.

2. Jin L, et al. Br J Cancer. 2011 Jan 4;104(1):91-100.

3. Kudo E, et al. Bioorg Med Chem Lett. 2013 Feb 1;23(3):606-9.

GUT-70 (GUT70)

生物&药学活性

物理化学性质&存储条件

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GUT-70 (GUT70)

生物&药学活性

物理化学性质&存储条件

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