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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Glutamate Transporter-GTS511
GTS511

Chemical Structure : GTS511

CAS No.: 920227-84-5

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GTS511 (GTS-511)

货号: PC-49854Not For Human Use, Lab Use Only.

GTS511 (GTS-511) is a potent, selective, brain-permeable activator of EAAT2 with EC50 of 3.8 nM in vitro glutamate uptake assays in COS cells overexpressing EAAT2.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    GTS511 (GTS-511) is a potent, selective, brain-permeable activator of EAAT2 with EC50 of 3.8 nM in vitro glutamate uptake assays in COS cells overexpressing EAAT2.
    GTS511 show a >6 h half-life and higher bioavailability in plasma and the brain under all three routes of administration in rats (intraperitoneal, IP, at 10 mg/kg; postoral, PO, at 10 mg/kg; and intravenous, IV, at 5 mg/kg).

    物理化学性质&存储条件

    分子量 339.40
    分子式 C19H21N3O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(4-methoxyphenyl)-2-oxo-2-(4-phenylpiperazin-1-yl)acetamide

    参考文献

    1. Sanjay Da, et al. ACS Med Chem Lett. 2022 Sep 19;13(10):1628-1633.

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