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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Glutamate Transporter-GTS467
GTS467

Chemical Structure : GTS467

CAS No.: 2752223-29-1

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GTS467 (GTS-467)

货号: PC-49856Not For Human Use, Lab Use Only.

GTS476 (GTS-476) is a potent, selective, orally active activator of EAAT2 with EC50 of 35.1 nM in vitro glutamate uptake assays in COS cells overexpressing EAAT2.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    GTS476 (GTS-476) is a potent, selective, orally active activator of EAAT2 with EC50 of 35.1 nM in vitro glutamate uptake assays in COS cells overexpressing EAAT2.
    GTS467 has high oral bioavailability (80–85%) in the brain and plasma with a >1 h half-life under all three dosing routes ((intraperitoneal, IP, at 10 mg/kg; postoral, PO, at 10 mg/kg; and intravenous, IV, at 5 mg/kg).

    物理化学性质&存储条件

    分子量 396.49
    分子式 C22H28N4O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N1-(4-methoxyphenyl)-N2-(2-(4-methylpiperazin-1-yl)-2-phenylethyl)oxalamide

    参考文献

    1. Sanjay Da, et al. ACS Med Chem Lett. 2022 Sep 19;13(10):1628-1633.

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