GTS-21 dihydrochloride

Chemical Structure : GTS-21 dihydrochloride

CAS No.: 156223-05-1

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货号: PC-23864Not For Human Use, Lab Use Only.

GTS-21 dihydrochloride (DMXBA) is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist, is also a α4β2 (Ki=20 nM for humanα4β2) and 5-HT3A receptor (IC50=3.1 μM) antagonist.

规格	价格	库存
5 mg	￥480	In stock
10 mg	￥780	In stock
50 mg	￥1880	In stock
100 mg		Get quote

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生物&药学活性

GTS-21 dihydrochloride (DMXBA) is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist, is also a α4β2 (Ki=20 nM for humanα4β2) and 5-HT3A receptor (IC50=3.1 μM) antagonist.
GTS-21 dihydrochloride (DMXBA) shows anti‑inflammatory and cognition‑enhancing activities.

物理化学性质&存储条件

分子量	381.30
分子式	C19H22Cl2N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(2,4-Dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3'-bipyridine dihydrochloride

参考文献

1. Meyer EM, et al. J Pharmacol Exp Ther. 1998 Dec;287(3):918-25.

2. Woodruff-Pak DS, et al. Brain Res. 1994 May 9;645(1-2):309-17.

3. Briggs CA, et al. Pharmacol Biochem Behav. 1997;57(1-2):231-241.

4. Zhang R, et al. J Pharmacol Exp Ther. 2006;317(3):1276-1284.