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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-nAChR-GTS-21
GTS-21

Chemical Structure : GTS-21

CAS No.:

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GTS-21 (DMXBA, DMBX-anabaseine)

货号: PC-23863Not For Human Use, Lab Use Only.

GTS-21 (DMXBA) is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist, is also a α4β2 (Ki=20 nM for humanα4β2) and 5-HT3A receptor (IC50=3.1 μM) antagonist.
GTS-21 (DMXBA) shows anti‑inflammatory and cognition‑enhancing activities.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

GTS-21 (DMXBA) is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist, is also a α4β2 (Ki=20 nM for humanα4β2) and 5-HT3A receptor (IC50=3.1 μM) antagonist.
GTS-21 (DMXBA) shows anti‑inflammatory and cognition‑enhancing activities.

物理化学性质&存储条件

分子量 308.38
分子式 C19H20N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-3-(2,4-dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3'-bipyridine

参考文献

1. Meyer EM, et al. J Pharmacol Exp Ther. 1998 Dec;287(3):918-25.

2. Woodruff-Pak DS, et al. Brain Res. 1994 May 9;645(1-2):309-17.

3. Briggs CA, et al. Pharmacol Biochem Behav. 1997;57(1-2):231-241.

4. Zhang R, et al. J Pharmacol Exp Ther. 2006;317(3):1276-1284.

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