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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Telomerase-GTC365
GTC365

Chemical Structure : GTC365

CAS No.: 80261-18-3

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GTC365 (NSC 177365, GTC-365)

货号: PC-63059Not For Human Use, Lab Use Only.

GTC-365 (NSC 177365) is a small drug-like pharmacological chaperone that induces cancer cell death by restoring tertiary DNA structures in mutant human telomerase reverse transcriptase (hTERT) promoters.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    GTC-365 (NSC 177365) is a small drug-like pharmacological chaperone that induces cancer cell death by restoring tertiary DNA structures in mutant human telomerase reverse transcriptase (hTERT) promoters.
    GTC-365 acts at an early step in the G-quadruplex folding pathway to redirect mutant promoter G-quadruplex misfolding, partially reinstates the correct folding pathway, and reduces hTERT activity through transcriptional repression.
    GTC-365 binds to WT and G124/125A telomeric G-quadruplexes with a similar binding affinity (Kd=400 nM).

    物理化学性质&存储条件

    分子量 493.542
    分子式 C23H23N7O4S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-[3-[[4-[(3-Nitroacridin-9-yl)amino]phenyl]sulfamoyl]propyl]guanidin

    参考文献

    1. Kang HJ, et al. J. Am. Chem. Soc., 2016, 138 (41), pp 13673–13692

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