GST-HG171 | SARS-CoV-2 3CLPro inhibitor | Probechem Biochemicals

Chemical Structure : GST-HG171

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GST-HG171 (Atilotrelvir)

货号: PC-22709Not For Human Use, Lab Use Only.

GST-HG171 (Atilotrelvir) is a potent, broad-spectrum, orally bioavailable small-molecule 3C-like (3CL) protease inhibitor, has broad-spectrum activity against different variants of SARS-CoV-2.

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生物&药学活性

GST-HG171 (Atilotrelvir) is a potent, broad-spectrum, orally bioavailable small-molecule 3C-like (3CL) protease inhibitor, has broad-spectrum activity against different variants of SARS-CoV-2.
GST-HG171 is more potent and effective than nirmatrelvir in preclinical studies both in vitro and in vivo.
GST-HG171 has broad-spectrum activity against different variants of SARS-CoV-2, including Beta, Delta, Omicron B.1.1.529, Omicron BA.4, BA.5 variants with 5-10-fold higher activity than nirmatrelvir.
GST-HG171 demonstrated higher efficacy than nirmatrelvir in reducing the viral load of lung tissue in mice infected with SARS-CoV-2 virus.

物理化学性质&存储条件

分子量	511.54
分子式	C24H32F3N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Spiro[2-azabicyclo[2.2.1]heptane-5,1′-cyclopropane]-3-carboxamide, N-[(1S)-1-cyano-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]-2-[(2S)-3,3-dimethyl-1-oxo-2-[(2,2,2-trifluoroacetyl)amino]butyl]-, (1S,3S,4R)-

参考文献

1. Zhou J, et al. Antimicrob Agents Chemother. 2024 Jul 11:e0053924.

GST-HG171 (Atilotrelvir)

生物&药学活性

物理化学性质&存储条件

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GST-HG171 (Atilotrelvir)

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物理化学性质&存储条件

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