GSM-776890 | γ-secretase modulator | Probechem Biochemicals

Chemical Structure : GSM-776890

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GSM-776890 (UCSD-776890)

货号: PC-22499Not For Human Use, Lab Use Only.

UCSD-776890 (UCSD-776890) is a potent, selective γ-secretase modulator with Aβ42 IC50 of 4.2 nM, Aβ40 IC50 of 80 nM, also shows EC50 of 18 nM for potentiating Aβ38 secretion.

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生物&药学活性

UCSD-776890 (UCSD-776890) is a potent, selective γ-secretase modulator with Aβ42 IC50 of 4.2 nM, Aβ40 IC50 of 80 nM, also shows EC50 of 18 nM for potentiating Aβ38 secretion.

物理化学性质&存储条件

分子量	436.47
分子式	C23H22F2N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(1-(3,5-difluorophenyl)ethyl)-6-(6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl)-4-methylpyridazin-3-amine

参考文献

1. Kevin D Rynearson, et al. J Exp Med. 2021 Apr 5;218(4):e20202560.

2. Pettersson M, et al. J Med Chem. 2024 Jun 7. doi: 10.1021/acs.jmedchem.4c00580.

GSM-776890 (UCSD-776890)

生物&药学活性

物理化学性质&存储条件

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GSM-776890 (UCSD-776890)

生物&药学活性

物理化学性质&存储条件

参考文献

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