GSM-1 | γ-secretase modulator | Probechem Biochemicals

Chemical Structure : GSM-1

CAS No.: 884600-68-4

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GSM-1 (GSM1)

货号: PC-35113Not For Human Use, Lab Use Only.

GSM-1 (GSM1) is a γ-secretase modulator that directly targets the transmembrane domain (TMD) 1 of presenilin 1, shows potent Aβ42-lowering effect (IC50=0.348 uM) in a cell-based assay.

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2 mg	￥2480	In stock
5 mg	￥3980	In stock
10 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

GSM-1 (GSM1) is a γ-secretase modulator that directly targets the transmembrane domain (TMD) 1 of presenilin 1, shows potent Aβ42-lowering effect (IC50=0.348 uM) in a cell-based assay.
GSM-1 does not affect total Aβ and its C-terminal counterpart product, APP intracellular domain (AICD), selectively reduced the Aβ42 generation accompanied by an increase in Aβ38 in in-vitro assay.
GSM-1 decreases the ratio of Aβ42 to Aβ40 to 60% in plasma and the ratio of Aβ42 to total Aβ to 65% in cerebrospinal fluid from baseline to postdosing in monkeys (30 mg/kg)

物理化学性质&存储条件

分子量	481.98
分子式	C26H31ClF3NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((2S,4R)-1-((R)-1-(4-chlorophenyl)-4-methylpentyl)-2-(4-(trifluoromethyl)phenyl)piperidin-4-yl)acetic acid

参考文献

1. Page RM, et al. J Biol Chem. 2010 Jun 4;285(23):17798-810.

2. Kretner B, et al. J Biol Chem. 2011 Apr 29;286(17):15240-51.

3. Ohki Y, et al. EMBO J. 2011 Oct 14;30(23):4815-24.

4. Ling IF, et al. Alzheimers Res Ther. 2015 Aug 5;7(1):55.

GSM-1 (GSM1)

生物&药学活性

物理化学性质&存储条件

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GSM-1 (GSM1)

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