GSK-963 | RIPK1 inhibitor | Probechem Biochemicals

Chemical Structure : GSK963

CAS No.: 2049868-46-2

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GSK963 (GSK-963, GSK 963, GSK'963)

货号: PC-60549Not For Human Use, Lab Use Only.

GSK-963 (GSK963) is a potent and selective inhibitor of RIP1 kinase (RIPK1) with IC50 of 29 nM in FP binding assays.

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10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3680	In stock
100 mg		Get quote

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生物&药学活性

GSK-963 (GSK963) is a potent and selective inhibitor of RIP1 kinase (RIPK1) with IC50 of 29 nM in FP binding assays.
GSK-963 displays excellent selectivity of against a panel of 339 kinases, including IDO.
GSK-963 efficiently blocks necroptosis in both murine and human cells with IC50 of 1 nM and 4 nM, respectively.
GSK-963 demonstrates much greater protection from hypothermia in model of TNF-induced sterile shock, compared with Necrostatin-1.

物理化学性质&存储条件

分子量	230.311
分子式	C14H18N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,2-Dimethyl-1-(5(S)-phenyl-4,5-dihydro-pyrazol-1-yl)-propan-1-one

参考文献

1. Berger SB, et al. Cell Death Discov. 2015 Jul 27;1:15009.

2. Rojas-Rivera D, et al. Cell Death Differ. 2017 Jun;24(6):1100-1110.

3. Lule S, et al. Stroke. 2017 Sep;48(9):2549-2556.

GSK963 (GSK-963, GSK 963, GSK'963)

生物&药学活性

物理化学性质&存储条件

参考文献

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GSK963 (GSK-963, GSK 963, GSK'963)

生物&药学活性

物理化学性质&存储条件

参考文献

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