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首页-小分子抑制剂&激动剂-Others-Other Targets-GSK898
GSK898

Chemical Structure : GSK898

CAS No.: 1953156-92-7

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GSK898 (GSK-898)

货号: PC-20933Not For Human Use, Lab Use Only.

GSK898 is a potent, highly selective kynurenine monooxygenase (KMO) inhibitor with pIC50 of 8.8.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

GSK898 is a potent, highly selective kynurenine monooxygenase (KMO) inhibitor with pIC50 of 8.8.
GSK898 shows no inhibitory effects on the other enzymes in the tryptophan metabolism pathway (IDO, TDO, KATI/II, kynureninase).
GSK898 rescues the phenotype, reducing 3-hydroxykynurenine and protecting against critical illness and death.

物理化学性质&存储条件

分子量 360.79
分子式 C18H17ClN2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(O)CCC1=NOC2=CC(O[C@@H](C3=NC=C(C)C=C3)C)=C(Cl)C=C12

参考文献

1. Alastair J Hayes, et al. Cell Rep. 2023 Jul 19;42(8):112763.

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