GSK621 |CAS:1346607-05-3 Probechem Biochemicals

Chemical Structure : GSK621

CAS No.: 1346607-05-3

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GSK621 (GSK 621;GSK-621)

货号: PC-35414Not For Human Use, Lab Use Only.

GSK621 (GSK-621) is a potent, specific AMPK agonist (activator), induces cytotoxicity in AML (IC50=13-30 uM) but not in normal hematopoietic cells.

规格	价格	库存
10 mg	￥1980	In stock
25 mg	￥2980	In stock
50 mg	￥4880	In stock
100 mg		Get quote

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生物&药学活性

GSK621 (GSK-621) is a potent, specific AMPK agonist (activator), induces cytotoxicity in AML (IC50=13-30 uM) but not in normal hematopoietic cells.
GSK621 is more potent than A-769662 at inducing AMPK activation, as measured by the level of ACC phosphorylation, markedly increases phosphorylation at AMPKα T172 in AML cell lines (MOLM-14, HL-60, and OCI-AML3) and primary AML samples.
Cytotoxicity in AML cells from GSK621 involves the eIF2α/ATF4 signaling pathway that specifically results from mTORC1 activation.

物理化学性质&存储条件

分子量	489.912
分子式	C26H20ClN3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	20 mM in DMSO (9.7 mg/mL) ultrasonic
Chemical Name/SMILES	6-chloro-5-(2'-hydroxy-3'-methoxy-[1,1'-biphenyl]-4-yl)-3-(3-methoxyphenyl)-1,5-dihydro-2H-pyrrolo[3,2-d]pyrimidine-2,4(3H)-dione

参考文献

1. Sujobert P, et al. Cell Rep. 2015 Jun 9;11(9):1446-57.

2. Jiang H, et al. PLoS One. 2016 Aug 17;11(8):e0161017.

3. Chen L, et al. Biochem Biophys Res Commun. 2016 Nov 25;480(4):515-521.

4. Liu W, et al. Oncotarget. 2017 Feb 7;8(6):10543-10552.

GSK621 (GSK 621;GSK-621)

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GSK621 (GSK 621;GSK-621)

生物&药学活性

物理化学性质&存储条件

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