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首页-小分子抑制剂&激动剂-GPCR-Relaxin Receptor -GSK618069
GSK618069

Chemical Structure : GSK618069

CAS No.:

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GSK618069 (GSK-618069)

货号: PC-22502Not For Human Use, Lab Use Only.

GSK618069 is a potent, selective antagonist of relaxin family peptide receptor 2 (RXFP2) with IC50 of 0.4 uM in HEK-hRXFP2 cAMP assays, 200-fold reduced potency against rRXFP2.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    GSK618069 is a potent, selective antagonist of relaxin family peptide receptor 2 (RXFP2) with IC50 of 0.4 uM in HEK-hRXFP2 cAMP assays, 200-fold reduced potency against rRXFP2.
    GSK618069 inhibits INSL3-stimulated CYP11B2 mRNA expression (IC50 = 2.8 µM) in adrenal cell assays.
    GSK618069 reduces aldosterone and cortisol synthesis and release.

    物理化学性质&存储条件

    分子量 473.63
    分子式 C27H35N7O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-cyclopentyl-4-(1-(piperidin-4-yl)-2-(pyridin-4-yl)-1H-benzo[d]imidazol-4-yl)piperazine-1-carboxamide

    参考文献

    1. Zhang SS, et al. Sci Rep. 2024 Jun 8;14(1):13209.

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