GSK598809 |CAS:863680-45-9 Probechem Biochemicals

Chemical Structure : GSK598809

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GSK598809 (GSK 598809;GSK-598809)

货号: PC-60743Not For Human Use, Lab Use Only.

GSK598809 (GSK-598809) is a potent, selective, CNS penetrant and orally bioavailable dopamine D3 receptor antagonist with pKi of 8.9.

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1 g		Get quote

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生物&药学活性

GSK598809 (GSK-598809) is a potent, selective, CNS penetrant and orally bioavailable dopamine D3 receptor antagonist with pKi of 8.9; displays >100-fold selectivity over D2 and H1 receptors; significantly attenuates the expression of conditioned place preference (CPP) to nicotine and cocaine; potentiates the hemodynamic effects of cocaine in dogs, also increases mean arterial blood pressure and heart rate in vivo.

Other Indication

Phase 2 Clinical

物理化学性质&存储条件

分子量	481.514
分子式	C22H23F4N5OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[2-Fluoro-4-(trifluoromethyl)phenyl]-3-[3-[[4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-4H-1,2,4-triazol-3-yl]thio]propyl]-3-azabicyclo[3.1.0]hexane

参考文献

1. Micheli F, et al. J Med Chem. 2010 Jan 14;53(1):374-91.

2. Appel NM, et al. J Pharmacol Exp Ther. 2015 Sep;354(3):484-92.

3. Dodds CM, et al. Appetite. 2012 Aug;59(1):27-33.

4. Searle G, et al. Biol Psychiatry. 2010 Aug 15;68(4):392-9.

GSK598809 (GSK 598809;GSK-598809)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

GSK598809 (GSK 598809;GSK-598809)

生物&药学活性

物理化学性质&存储条件

参考文献

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