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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-GSK591
GSK591

Chemical Structure : GSK591

CAS No.: 1616391-87-7

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GSK591 (EPZ015866, GSK-591, GSK3203591)

货号: PC-42097Not For Human Use, Lab Use Only.

GSK591 (EPZ015866, GSK3203591) is a potent, selective protein methyltransferase 5 (PRMT5) inhibitor with IC50 of 4 nM.

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10 mg ￥1480 In stock
25 mg ￥2680 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GSK591 (EPZ015866, GSK3203591) is a potent, selective protein methyltransferase 5 (PRMT5) inhibitor with IC50 of 4 nM.
GSK591 (EPZ015866, GSK3203591) shows excellent selectivity against other PMT enzymes observed with EPZ015666.
GSK591 (EPZ015866, GSK3203591) inhibits the proliferation of Z-138 cells with IC50 of 62 nM.

物理化学性质&存储条件

分子量 380.4833
分子式 C22H28N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-Pyridinecarboxamide, 2-(cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-

参考文献

1. Duncan KW, et al. ACS Med Chem Lett. 2015 Dec 2;7(2):162-6.

2. Gerhart SV, et al. Sci Rep. 2018 Jun 26;8(1):9711.

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