GSK549 | BET BD2 inhibitor | Probechem Biochemicals

Chemical Structure : GSK549

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货号: PC-72180Not For Human Use, Lab Use Only.

GSK549 (GSK-549) is a potent, highly selective, BD2 domain-selective BET inhibitor with pIC50 of 7.8 (BRD4 BD2), 1150-fold selectivity over BD1.

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GSK549 (GSK-549) is a potent, highly selective, BD2 domain-selective BET inhibitor with pIC50 of 7.8 (BRD4 BD2), 1150-fold selectivity over BD1.

分子量	366.421
分子式	C20H22N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N5-Cyclopropyl-1-(indolin-4-ylmethyl)-N3 -methyl-2-oxo-1,2-dihydropyridine-3,5-dicarboxamide

1. Seal JT, et al. J Med Chem. 2020 Sep 10;63(17):9093-9126.

2. Harrison LA, et al. J Med Chem. 2021 Aug 12;64(15):10742-10771.