GSK547 |CAS:2226735-55-1 Probechem Biochemicals

Chemical Structure : GSK547

CAS No.: 2226735-55-1

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GSK547 (GSK'547; RIP1i; GSK 547; GSK-547)

货号: PC-35793Not For Human Use, Lab Use Only.

GSK547 (RIP1i, GSK'547, GSK 547) is a highly selective and potent inhibitor of RIP1 kinase that robustly targets RIP1 in vivo.

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥1980	In stock
25 mg	￥2980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

GSK547 (RIP1i, GSK'547) is a highly selective and potent inhibitor of RIP1 kinase that robustly targets RIP1 in vivo.
GSK547 exhibited a 400-fold improvement in mouse pharmacokinetic oral exposure compared with GSK'963.
GSK547 reprogrammed TAMs toward an MHCIIhiTNFα+IFNγ+ immunogenic phenotype in a STAT1-dependent manner.
RIP1 inhibition in TAMs resulted in cytotoxic T cell activation and T helper cell differentiation toward a mixed Th1/Th17 phenotype, leading to tumor immunity in mice and in organotypic models of human Pancreatic ductal adenocarcinoma (PDA).

物理化学性质&存储条件

分子量	396.402
分子式	C20H18F2N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-6-(4-(5-(3,5-difluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbonyl)piperidin-1-yl)pyrimidine-4-carbonitrile

参考文献

1. Wang W, et al. Cancer Cell. 2018 Nov 12;34(5):757-774.e7.

GSK547 (GSK'547; RIP1i; GSK 547; GSK-547)

生物&药学活性

物理化学性质&存储条件

参考文献

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GSK547 (GSK'547; RIP1i; GSK 547; GSK-547)

生物&药学活性

物理化学性质&存储条件

参考文献

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