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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Estrogen Receptor/ERR-GSK5182
GSK5182

Chemical Structure : GSK5182

CAS No.: 877387-37-6

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GSK5182 (GSK-5182)

货号: PC-72965Not For Human Use, Lab Use Only.

GSK5182 (GSK-5182) is a highly selective and orally active inverse agonist of estrogen-related receptor γ (ERRγ) with IC50 of 79 nM.

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10 mg ￥1580 In stock
25 mg ￥2580 In stock
50 mg ￥3980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GSK5182 (GSK-5182) is a highly selective and orally active inverse agonist of estrogen-related receptor γ (ERRγ) with IC50 of 79 nM.
GSK5182 displays little to no activities against other nuclear receptors, including ERRα or ERα.

物理化学性质&存储条件

分子量 417.549
分子式 C27H31NO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

100 mM in DMSO (41.7 mg/mL)
Chemical Name/SMILES

(Z)-4-(1-(4-(2-(dimethylamino)ethoxy)phenyl)-5-hydroxy-2-phenylpent-1-en-1-yl)phenol

参考文献

1. Kim DK, et al. J Biol Chem. 2011 Nov 4;286(44):38035-38042.

2. Zhang Y, et al. Biochem J. 2015 Sep 1;470(2):181-93.

3. Xie YB, et al. J Biol Chem. 2009 Oct 16;284(42):28762-74.

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