GSK484 hydrochloride | PAD4 inhibitor | Probechem Biochemicals

Chemical Structure : GSK484 hydrochloride

CAS No.: 1652591-81-5

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GSK484 hydrochloride (GSK-484)

货号: PC-62215Not For Human Use, Lab Use Only.

GSK484 hydrochloride is a potent, highly selective and reversible protein arginine deiminase PAD4 inhibitor with IC50 of 80 nM in FP binding assay (0.2 mM Ca), 50 nM in PAD4 NH3 release inhibition assay.

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3880	In stock
50 mg	￥5780	In stock
100 mg		Get quote

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生物&药学活性

GSK484 hydrochloride is a potent, highly selective and reversible protein arginine deiminase PAD4 inhibitor with IC50 of 80 nM in FP binding assay (0.2 mM Ca), 50 nM in PAD4 NH3 release inhibition assay.
GSK484 shows high specificity for PAD4 over PAD1/2/3/6.
GSK484 causes a clear, statistically-significant reduction in diffused NETs.

物理化学性质&存储条件

分子量	510.035
分子式	C27H32ClN5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	[(3S,4R)-3-amino-4-hydroxy-1-piperidinyl][2-[1-(cyclopropylmethyl)-1H-indol-2-yl]-7-methoxy-1-methyl-1H-benzimidazol-5-yl]-methanone hydrochloride

参考文献

1. Lewis HD, et al. Nat Chem Biol. 2015 Mar;11(3):189-91.

2. Cedervall J, et al. Oncoimmunology. 2017 Apr 20;6(8):e1320009.

GSK484 hydrochloride (GSK-484)

生物&药学活性

物理化学性质&存储条件

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GSK484 hydrochloride (GSK-484)

生物&药学活性

物理化学性质&存储条件

参考文献

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