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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Protein Arginine Deiminase (PAD)-GSK484
GSK484

Chemical Structure : GSK484

CAS No.: 1652629-23-6

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GSK484 (MMV1793192, GSK-484)

货号: PC-62214Not For Human Use, Lab Use Only.

GSK484 (MMV1793192) is a potent, highly selective and reversible protein arginine deiminase PAD4 inhibitor with IC50 of 80 nM in FP binding assay (0.2 mM Ca),

规格 价格 库存 数量
5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3780 In stock
50 mg ￥5880 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GSK484 (MMV1793192) is a potent, highly selective and reversible protein arginine deiminase PAD4 inhibitor with IC50 of 80 nM in FP binding assay (0.2 mM Ca), 50 nM in PAD4 NH3 release inhibition assay.
GSK484 shows high specificity for PAD4 over PAD1/2/3/6.
GSK484 causes a clear, statistically-significant reduction in diffused NETs.

物理化学性质&存储条件

分子量 473.577
分子式 C27H31N5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

[(3S,4R)-3-amino-4-hydroxy-1-piperidinyl][2-[1-(cyclopropylmethyl)-1H-indol-2-yl]-7-methoxy-1-methyl-1H-benzimidazol-5-yl]-methanone

参考文献

1. Lewis HD, et al. Nat Chem Biol. 2015 Mar;11(3):189-91.

2. Cedervall J, et al. Oncoimmunology. 2017 Apr 20;6(8):e1320009.

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