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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-ROCK-GSK429286A
GSK429286A

Chemical Structure : GSK429286A

CAS No.: 864082-47-3

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GSK429286A (GSK 429286A;GSK-429286A)

货号: PC-42776Not For Human Use, Lab Use Only.

GSK429286A is a poten and selective inhibitor ROCK1 (IC50=14 nM) and ROCK2 (IC50=63 nM).

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5 mg (Free Sample) ￥280 In stock
25 mg ￥1380 In stock
50 mg ￥2480 In stock
100 mg ￥3980 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GSK429286A is a poten and selective inhibitor ROCK1 (IC50=14 nM) and ROCK2 (IC50=63 nM).
GSK429286A inhibits RSK and p70S6K with IC50 of 0.78 μM and 1.94 μM, respectively.
GSK429286A has oral bioavailability.

物理化学性质&存储条件

分子量 432.3709
分子式 C21H16F4N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
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Solubility

DMSO: ≥ 51 mg/mL
Chemical Name/SMILES

3-Pyridinecarboxamide, N-(6-fluoro-1H-indazol-5-yl)-1,4,5,6-tetrahydro-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-

参考文献

1. Goodman KB, et al. J Med Chem. 2007 Jan 11;50(1):6-9.

2. Nichols RJ, et al. Biochem J, 2009, 424(1), 47-60.

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