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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Rev-ErbA-GSK4112
GSK4112

Chemical Structure : GSK4112

CAS No.: 1216744-19-2

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GSK4112 (SR6452;GSK-4112;GSK 4112;SR-6452;SR 6452)

货号: PC-43929Not For Human Use, Lab Use Only.

GSK4112 (SR6452) is a potent and selective small molecule Rev-erbα agonist with EC50 of 0.4 uM in biochemical assays.

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10 mg ￥880 In stock
25 mg ￥1480 In stock
50 mg ￥2480 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GSK4112 (SR6452) is a potent and selective small molecule Rev-erbα agonist with EC50 of 0.4 uM in biochemical assays.
GSK4112 mediates the repression of Rev-erbα target gene bmal1 in liver cells, and inhibits and shifts the phase of gluconeogenesis in primary mouse hepatocytes.

物理化学性质&存储条件

分子量 396.8883
分子式 C18H21ClN2O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Glycine, N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl]-, 1,1-dimethylethyl ester

参考文献

1. Grant D, et al. ACS Chem Biol. 2010 Oct 15;5(10):925-32.

2. Trump RP, et al. J Med Chem. 2013 Jun 13;56(11):4729-37.

3. Chandra V, et al. Autophagy. 2015 Nov 2;11(11):1987-1997.

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