GSK3β-Nav1.6 inhibitor 1063

Chemical Structure : GSK3β-Nav1.6 inhibitor 1063

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货号: PC-25144Not For Human Use, Lab Use Only.

GSK3β-Nav1.6 inhibitor 1063 is a brain-penetrant small molecule that selectively disrupts GSK3β/Nav1.6 complex formation (IC50=26.2 uM) and inhibits Nav1.6 currents in an isoform-specific manner.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

GSK3β-Nav1.6 inhibitor 1063 is a brain-penetrant small molecule that selectively disrupts GSK3β/Nav1.6 complex formation (IC50=26.2 uM) and inhibits Nav1.6 currents in an isoform-specific manner.
Compound 1063 is functionally specific for Nav1.6 over other central nervous system (CNS) Nav isoforms.
Compound 1063 reduces hippocampal hyperexcitability through a GSK3β-dependent mechanism and dose-dependently suppresses epileptiform spikes in early-stage AD mouse models.

物理化学性质&存储条件

分子量	338.47
分子式	C17H26N2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl 2-(2-(isopropylamino)acetamido)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate

参考文献

1. Baumgartner TJ, et al. Alzheimers Dement. 2025 Jul;21(7):e70507.