GSK356278 | PDE4 inhibitor | Probechem Biochemicals

Chemical Structure : GSK356278

CAS No.: 720704-34-7

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GSK356278 (GSK-356278)

货号: PC-60657Not For Human Use, Lab Use Only.

GSK356278 is a potent, selective, brain-penetrant and orally bioavailable phosphodiesterase 4 (PDE4) inhibitor with pIC50 of 8.8 (PDE4B).

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2480	In stock
100 mg	￥3980	In stock
250 mg		Get quote

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生物&药学活性

GSK356278 is a potent, selective, brain-penetrant and orally bioavailable phosphodiesterase 4 (PDE4) inhibitor with pIC50 of 8.8 (PDE4B).
GSK356278 equally inhibits PDE4A and PDE4Dwith pIC50 of 8.6 and 8.7, exhibits >100-fold selectivity for PDE4B over the other 10 PDEs.
GSK356278 inhibits LPS-induced release of TNF-α in human whole blood with pIC50 of 7.6, demonstrates anxiolytic and cognition-enhancing effects without inducing side effects in models of anxiety.

物理化学性质&存储条件

分子量	439.538
分子式	C21H25N7O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(5-((2,4-dimethylthiazol-5-yl)methyl)-1,3,4-oxadiazol-2-yl)-1-ethyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine

参考文献

1. Rutter AR, et al. J Pharmacol Exp Ther. 2014 Jul;350(1):153-63.

2. van der Aart J, et al. J Cereb Blood Flow Metab. 2017 Jan 1:271678X17720868.

GSK356278 (GSK-356278)

生物&药学活性

物理化学性质&存储条件

参考文献

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GSK356278 (GSK-356278)

生物&药学活性

物理化学性质&存储条件

参考文献

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