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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-GSK3527497
GSK3527497

Chemical Structure : GSK3527497

CAS No.: 2215855-22-2

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GSK3527497 (GSK-3527497)

货号: PC-73096Not For Human Use, Lab Use Only.

GSK3527497 (GSK-3527497) is a potent, selective TRPV4 inhibitor with IC50 of 12 nM (hTRPV4).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    GSK3527497 (GSK-3527497) is a potent, selective TRPV4 inhibitor with IC50 of 12 nM (hTRPV4).
    GSK3527497 is a pre-clinical candidate for treatment of diseases resulting from TRPV4 activation.

    物理化学性质&存储条件

    分子量 426.847
    分子式 C17H16ClFN4O4S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(((3S,4S)-4-(Aminomethyl)-1-((5-chloropyridin-2-yl)-sulfonyl)-4-hydroxypyrrolidin-3-yl)oxy)-2-fluorobenzonitrile

    参考文献

    1. Carl A Brooks, et al. J Med Chem. 2019 Oct 24;62(20):9270-9280.

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