GSK3395879 |CAS:2215852-91-6 Probechem Biochemicals

Chemical Structure : GSK3395879

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GSK3395879 (GSK-3395879;GSK 3395879)

货号: PC-35713Not For Human Use, Lab Use Only.

GSK3395879 (GSK-3395879) is a novel potent, selective, orally bioavailable antagonist of TRPV4 with IC50 of 1 nM (hTRPV4).

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生物&药学活性

GSK3395879 (GSK-3395879) is a novel potent, selective, orally bioavailable antagonist of TRPV4 with IC50 of 1 nM (hTRPV4).
GSK3395879 exhibits little or no activity against a broad panel of TRP channels (IC50 > 10µM for TRPA1, TRPV1, TRPM2, TRPM4, TRPM8, TRPC3, TRPC4, TRPC5, TRPC6).
GSK3395879 demonstrates the ability to inhibit TRPV4-mediated pulmonary edema in an in vivo rat model.

物理化学性质&存储条件

分子量	485.41
分子式	C20H15F4N3O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(((3S,4R)-1-((2-cyano-4-(trifluoromethyl)phenyl)sulfonyl)-4-hydroxy-4-(hydroxymethyl)pyrrolidin-3-yl)oxy)-2-fluorobenzonitrile

参考文献

1. Brnardic EJ, et al. J Med Chem. 2018 Oct 18. doi: 10.1021/acs.jmedchem.8b01317.

GSK3395879 (GSK-3395879;GSK 3395879)

生物&药学活性

物理化学性质&存储条件

参考文献

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GSK3395879 (GSK-3395879;GSK 3395879)

生物&药学活性

物理化学性质&存储条件

参考文献

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