GSK3008348 | αvβ6 integrin inhibitor | Probechem Biochemicals

Chemical Structure : GSK3008348

CAS No.: 1629249-33-7

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GSK3008348 (GSK-3008348)

货号: PC-60069Not For Human Use, Lab Use Only.

GSK3008348 is a potent, selective, RGD-mimetic integrin αvβ6 antagonist with KD value of 9.5 pM and 4.8 pM for αvβ6 in normal and IPF human lung tissue membrane preparations.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

GSK3008348 is a potent, selective, RGD-mimetic integrin αvβ6 antagonist with KD value of 9.5 pM and 4.8 pM for αvβ6 in normal and IPF human lung tissue membrane preparations.

GSK3008348 exhibits a high affinity and a minimum of 26-fold selectivity for the αvβ6 integrin over the other RGD integrin family members.

GSK3008348 induces αvβ6 internalization and degradation in human lung epithelial cells.

GSK3008348 engages αvβ6, induces prolonged inhibition of TGFβ signaling and reduces lung collagen deposition and serum C3M, a marker of IPF disease progression, in murine bleomycin-induced lung fibrosis model.

物理化学性质&存储条件

分子量	487.636
分子式	C29H37N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S)-3-[3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl]-4-{(3S)-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-1-pyrrolidinyl}butanoic acid

参考文献

1. John AE, et al. Nat Commun. 2020 Sep 16;11(1):4659.

GSK3008348 (GSK-3008348)

生物&药学活性

物理化学性质&存储条件

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GSK3008348 (GSK-3008348)

生物&药学活性

物理化学性质&存储条件

参考文献

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