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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Rev-ErbA-GSK2945
GSK2945

Chemical Structure : GSK2945

CAS No.: 1438071-12-5

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GSK2945 (GSK-2945)

货号: PC-62690Not For Human Use, Lab Use Only.

GSK2945 is a potent and selective small molecule Rev-Erbα agonist with EC50 of 50 nM, displays >1,000-fold selectivity over LXRα.

规格 价格 库存 数量
10 mg ￥1980 In stock
25 mg ￥3280 In stock
50 mg ￥5480 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GSK2945 is a potent and selective small molecule Rev-Erbα agonist with EC50 of 50 nM, displays >1,000-fold selectivity over LXRα.
GSK2945 inhibits LPS induction of IL-6 production and to upregulate expression of ABCA1 in human THP-1 cells.
GSK2945 demonstrates in vivo bioavailability and orally active.

物理化学性质&存储条件

分子量 421.336
分子式 C20H18Cl2N2O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-chloro-2-methylbenzyl)-N-(4-chlorobenzyl)-1-(5-nitrothiophen-2-yl)methanamine

参考文献

1. Trump RP, et al. J Med Chem. 2013 Jun 13;56(11):4729-37.

2. Zhang T, et al. Drug Metab Dispos. 2018 Mar;46(3):248-258.

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