GSK2837808A | LDHA inhibitor | Probechem Biochemicals

Chemical Structure : GSK2837808A

CAS No.: 1445879-21-9

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GSK2837808A (GSK 2837808A)

货号: PC-61222Not For Human Use, Lab Use Only.

GSK2837808A is a potent, specific, NADH-competitive lactate dehydrogenase-A (LDHA) inhibitor with IC50 of 2.6 nM, >10-fold selectivity over LDHB.

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5 mg	￥1480	In stock
10 mg	￥2380	In stock
25 mg	￥4280	In stock
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100 mg		Get quote

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生物&药学活性

GSK2837808A is a potent, specific, NADH-competitive lactate dehydrogenase-A (LDHA) inhibitor with IC50 of 2.6 nM, >10-fold selectivity over LDHB.
GSK2837808A rapidly and profoundly inhibits lactate production rates in multiple cancer cell lines (EC50=0.4 uM in Snu398 cells) including hepatocellular and breast carcinomas.
GSK2837808A reduces glucose uptake and increases mitochondrial oxygen consumption, dose dependently inhibits proliferation and induces apoptosis in Snu398 cells.

物理化学性质&存储条件

分子量	649.626
分子式	C31H25F2N5O7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(3,5-difluorophenoxy)benzoic acid

参考文献

1. Xie H, et al. Cell Metab. 2014 May 6;19(5):795-809.

2. Billiard J, et al. Cancer Metab. 2013 Sep 6;1(1):19.

GSK2837808A (GSK 2837808A)

生物&药学活性

物理化学性质&存储条件

参考文献

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GSK2837808A (GSK 2837808A)

生物&药学活性

物理化学性质&存储条件

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