GSK 2833503A |CAS:1366234-01-6 Probechem Biochemicals

Chemical Structure : GSK 2833503A

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GSK 2833503A (GSK2833503A;GSK503A)

货号: PC-70337Not For Human Use, Lab Use Only.

GSK 2833503A (GSK2833503A, GSK503A) is a potent, and selective inhibitor of TRPC3/6 channels with IC50 of 4 nM/5 nM, respectively.

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生物&药学活性

GSK 2833503A (GSK2833503A, GSK503A) is a potent, and selective inhibitor of TRPC3/6 channels with IC50 of 4 nM/5 nM, respectively.
GSK 2833503A dispalys >100-fold selectivity over other calcium-permeable channels.
GSK 2833503A shows 100-fold greater potency for TRPC3 compared with Pyr3.
GSK 2833503A dose-dependent blocks cell hypertrophy signaling triggered by angiotensin II or endothelin-1 in HEK293T cells as well as in neonatal and adult cardiac myocytes.

物理化学性质&存储条件

分子量	381.894
分子式	C18H21ClFN3OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2-((4-chloro-2-fluorophenyl)amino)-5-methylthiazol-4-yl)((2S,3S)-2,3-dimethylpiperidin-1-yl)methanone

参考文献

1. Seo K, et al. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1551-6.

2. Washburn DG, et al. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4979-84.

GSK 2833503A (GSK2833503A;GSK503A)

生物&药学活性

物理化学性质&存储条件

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GSK 2833503A (GSK2833503A;GSK503A)

生物&药学活性

物理化学性质&存储条件

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