GSK2818713 | HCV NS5A inhibitor | Probechem Biochemicals

Chemical Structure : GSK2818713

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GSK2818713 (GSK-2818713)

货号: PC-72397Not For Human Use, Lab Use Only.

GSK2818713 (GSK-2818713) is a nonstructural protein 5A (NS5A) HCV inhibitor with broad genotype coverage.

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生物&药学活性

GSK2818713 (GSK-2818713) is a nonstructural protein 5A (NS5A) HCV inhibitor with broad genotype coverage.
GSK2818713 significantly improved genotype coverage relative to first-generation NS5A inhibitor daclatasvir (DCV).
GSK2818713 improved activity against genotype 1a (gt1a) and gt1b NS5A variants as well as HCV chimeric replicons containing NS5A fragments from genotypes 2-6.
GSK2818713 potently and durably decreased HCV RNA levels for gt1a, gt2a, and gt3a in replicon assays.

物理化学性质&存储条件

分子量	C46H56N8O8
分子式	849.002
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	dimethyl ((2S,2'S,3R,3'R)-((2S,2'S,3aS,3a'S,6aS,6a'S)-(biphenylene-2,6-diylbis(1H-imidazole-5,2-diyl))bis(hexahydrocyclopenta[b]pyrrole-2,1(2H)-diyl))bis(3-methoxy-1-oxobutane-1,2-diyl))dicarbamate

参考文献

1. Wieslaw M Kazmierski, et al. J Med Chem. 2020 Apr 23;63(8):4155-4170.

GSK2818713 (GSK-2818713)

生物&药学活性

物理化学性质&存储条件

参考文献

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GSK2818713 (GSK-2818713)

生物&药学活性

物理化学性质&存储条件

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