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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-GSK2798745
GSK2798745

Chemical Structure : GSK2798745

CAS No.: 1419609-94-1

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GSK2798745 (GSK-2798745)

货号: PC-72599Not For Human Use, Lab Use Only.

GSK2798745 (GSK-2798745) is a potent, selective TRPV4 inhibitor with IC50 of 1.8/1.6 nM (hTRPV4/rTRPV4).

规格 价格 库存 数量
2 mg ￥3580 In stock
5 mg ￥5580 In stock
10 mg ￥8980 In stock
25 mg Get quote
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GSK2798745 (GSK-2798745) is a potent, selective TRPV4 inhibitor with IC50 of 1.8/1.6 nM (hTRPV4/rTRPV4).
GSK2798745 displays excellent TRP selectivity (M5, A1, C3, and C6 >25 uM, and efficacy in an in vivo rat PK/PD model of pulmonary edema.

物理化学性质&存储条件

分子量 460.538
分子式 C25H28N6O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(((5S,7S)-3-(5-(2-Hydroxypropan-2-yl)pyrazin-2-yl)-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl)methyl)-1H-benzo[d]imidazole-6-carbonitrile

参考文献

1. Brooks CA, et al. ACS Med Chem Lett. 2019 Jul 15;10(8):1228-1233.

2. Ludbrook VJ, et al. ERJ Open Res. 2021 Aug 2;7(3):00269-2021.

3. Xu X, et al. J Pharmacol Exp Ther. 2021 Mar;376(3):436-443.

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