GSK 2793660 |CAS:1613458-79-9 Probechem Biochemicals

Chemical Structure : GSK 2793660

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GSK 2793660 (GSK2793660;GSK-2793660)

货号: PC-60946Not For Human Use, Lab Use Only.

GSK 2793660 (GSK2793660) is a potent, selective, irreversible and orally bioavailable cathepsin C (CTSC) inhibitor with IC50 of 0.43-1 nM.

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生物&药学活性

GSK 2793660 (GSK2793660) is a potent, selective, irreversible and orally bioavailable cathepsin C (CTSC) inhibitor with IC50 of 0.43-1 nM.
GSK 2793660 does not inhibits the activity of downstream neutrophil serine proteases.
GSK 2793660 shows potential for the treatment of cystic fibrosis, non-cystic fibrosis bronchiectasis, ANCA-associated vasculitis and bronchiectasis.

物理化学性质&存储条件

分子量	421.966
分子式	C22H32ClN3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S,E)-4-amino-N-(1-(indolin-1-yl)-6-methyl-1-oxohept-2-en-4-yl)tetrahydro-2H-pyran-4-carboxamide hydrochloride

参考文献

1. Miller BE, et al. Br J Clin Pharmacol. 2017 Dec;83(12):2813-2820.

2. Szcześniak P, et al. J Org Chem. 2016 Feb 5;81(3):1057-74.

GSK 2793660 (GSK2793660;GSK-2793660)

生物&药学活性

物理化学性质&存储条件

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GSK 2793660 (GSK2793660;GSK-2793660)

生物&药学活性

物理化学性质&存储条件

参考文献

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