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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Syk-GSK2646264
GSK2646264

Chemical Structure : GSK2646264

CAS No.: 1398695-47-0

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GSK2646264 (GSK-2646264;GSK 2646264)

货号: PC-35689Not For Human Use, Lab Use Only.

GSK2646264 (GSK-2646264) is a potent, selective Spleen Tyrosine Kinase (Syk) inhibitor with pIC50 of 7.1, >300-fold selectivity over Autota B.

规格 价格 库存 数量
2 mg ￥3980 In stock
5 mg ￥5980 In stock
10 mg ￥8980 In stock
25 mg Get quote
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GSK2646264 (GSK-2646264) is a potent, selective Spleen Tyrosine Kinase (Syk) inhibitor with pIC50 of 7.1, >300-fold selectivity over Autota B。
GSK2646264 inhibits anti-IgM induced Erk1/2 phosphorylation in Ramos B cells with pIC50 of 6.7.

物理化学性质&存储条件

分子量 374.484
分子式 C24H26N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

7-(2-methoxy-6-((4-methylpyridin-2-yl)methoxy)phenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine

参考文献

1. Barker MD, et al. Bioorg Med Chem Lett. 2018 Nov 15;28(21):3458-3462.

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