GSK2643943A | USP20 inhibitor | Probechem Biochemicals

Chemical Structure : GSK2643943A

CAS No.: 2449301-27-1

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GSK2643943A (GSK-2643943A)

货号: PC-20184Not For Human Use, Lab Use Only.

GSK2643943A is a specific, cell penetrant small molecule inhibitor of deubiquitinating enzyme USP20 with IC50 of 160 nM (USP20/Ub-Rho).

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5 mg	￥1780	In stock
10 mg	￥2880	In stock
25 mg	￥4980	In stock
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100 mg		Get quote

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生物&药学活性

GSK2643943A is a specific, cell penetrant small molecule inhibitor of deubiquitinating enzyme USP20 with IC50 of 160 nM (USP20/Ub-Rho).
GSK2643943A blocked the USP20-mediated cleavage of protein-ubiquitin bonds.
GSK2643943A (1 uM) influences oHSV-1 T1012G productive infection and viability in SCC9 cells.
GSK2643943A treatment potentiated oHSV-1-induced oncolysis in SCC9 tumors.
GSK2643943A treatment boosted the anti-tumor effects of oHSV-1 T1012G in SCC7 tumors in mice.

物理化学性质&存储条件

分子量	277.30
分子式	C17H12FN3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-2-amino-6-(3-fluorostyryl)-1H-indole-3-carbonitrile

参考文献

1. Lu R, et al. Mol Ther Oncolytics. 2021 Nov 11;23:477-487.

2. Mark Kemp. Prog Med Chem. 2016; 55: 149–192.

3. Biju M, et al. Discovery of potent and selective small molecule USP20 inhibitors. Poster presented at ubiquitin drug discovery and diagnostics, Philadelphia; 2012.

GSK2643943A (GSK-2643943A)

生物&药学活性

物理化学性质&存储条件

参考文献

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GSK2643943A (GSK-2643943A)

生物&药学活性

物理化学性质&存储条件

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