GSK2636771 | PI3Kβ inhibitor | Probechem Biochemicals

Chemical Structure : GSK2636771

CAS No.: 1372540-25-4

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GSK2636771 (GSK 2636771)

货号: PC-21944Not For Human Use, Lab Use Only.

GSK2636771 is a potent, selective and orally bioavailable inhibitor of PI3Kβ with Ki/IC50 of 0.89/5.2 nM, respectively.

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥3980	In stock
100 mg		Get quote

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生物&药学活性

GSK2636771 is a potent, selective and orally bioavailable inhibitor of PI3Kβ with Ki/IC50 of 0.89/5.2 nM, respectively.
GSK2636771 displays 900-fold selectivity over p110α and p110γ, and 10-fold selectivity over p110δ isoforms.
GSK2636771 causes cell viability significantly more decreased in the control cells (p110β-reliant PTEN-deficient PC3 prostate and BT549 and HCC70 breast cancer cell lines) than in PTEN-mutant and PTEN wild-type EEC cells.
GSK2636771 decreases AKT phosphorylation in prostate and breast cancer cell lines, suppresses cell and tumor growth in vivo.

物理化学性质&存储条件

分子量	433.43
分子式	C22H22F3N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Methyl-1-(2-methyl-3-(trifluoromethyl)benzyl)-6-morpholino-1H-benzo[d]imidazole-4-carboxylic acid

参考文献

1. Weigelt B, et al. Clin Cancer Res. 2013 Jul 1;19(13):3533-44.

GSK2636771 (GSK 2636771)

生物&药学活性

物理化学性质&存储条件

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GSK2636771 (GSK 2636771)

生物&药学活性

物理化学性质&存储条件

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