GSK2593074A |CAS:1337531-06-2 Probechem Biochemicals

Chemical Structure : GSK2593074A

CAS No.: 1337531-06-2

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GSK2593074A (GSK'074;GSK-2593074A)

货号: PC-36135Not For Human Use, Lab Use Only.

GSK2593074A (GSK'074, GSK-2593074A) is novel potent, selective RIP1/RIP3 kinase dual inhibitor, directly binds to RIP1 and RIP3 with Kd of 130 and 12 nM, respectively.

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5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

GSK2593074A (GSK'074, GSK-2593074A) is novel potent, selective RIP1/RIP3 kinase dual inhibitor, directly binds to RIP1 and RIP3 with Kd of 130 and 12 nM, respectively.
GSK2593074A potently inhibits necroptosis in various cell types (IC50=3 nM both in MOVAS and L929 cells), blocks necroptosis signaling pathway.
GSK2593074A inhibits RIP3-dependent RIP1-independent necroptosis and inflammation, but does not induce apoptosis.
GSK2593074A attenuates cell death and inflammation in calcium phosphate injured aortae.

物理化学性质&存储条件

分子量	465.575
分子式	C27H23N5OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(5-(4-amino-7-(1-methyl-1H-pyrazol-4-yl)thieno[3,2-c]pyridin-3-yl)indolin-1-yl)-2-phenylethan-1-one

参考文献

1. Zhou T, et al. Cell Death Dis. 2019 Mar 6;10(3):226.

GSK2593074A (GSK'074;GSK-2593074A)

生物&药学活性

物理化学性质&存储条件

参考文献

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GSK2593074A (GSK'074;GSK-2593074A)

生物&药学活性

物理化学性质&存储条件

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