GSK256073 | GPR109A agonist | Probechem Biochemicals

Chemical Structure : GSK256073

CAS No.: 862892-90-8

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GSK256073 (GSK 256073)

货号: PC-21439Not For Human Use, Lab Use Only.

GSK256073 is a highly potent, selective agonist of hydroxy-carboxylic acid receptor 2 (HCA2, HM74A/GPR109A) with pEC50 of 7.5, 100-fold selective over HCA3 (pEC50=5.6).

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4780	In stock
100 mg		Get quote

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生物&药学活性

GSK256073 is a highly potent, selective agonist of hydroxy-carboxylic acid receptor 2 (HCA2, HM74A/GPR109A) with pEC50 of 7.5, 100-fold selective over HCA3 (pEC50=5.6).
GSK256073 is a full and potent agonist (pEC50=6.48) at human adipocyte membranes using a [35S]GTP-γS binding assay.
GSK256073 does not display significant activity against a number of 7-transmembrane receptors, ion channels, transporters, and phophodiesterases.
GSK256073 (0.03, 0.3, 3.0 and 30 mg/kg) inhibited triglyceride accumulation by 7%, 30%, 51% and 78%, respectively, in rats.

物理化学性质&存储条件

分子量	256.69
分子式	C10H13ClN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-chloro-3-pentyl-7H-purine-2,6-dione

参考文献

1. Sprecher D, et al. Eur J Pharmacol. 2015 Jun 5;756:1-7.

2. Dobbins R, et al. Eur J Pharmacol. 2015 May 15;755:95-101.

GSK256073 (GSK 256073)

生物&药学活性

物理化学性质&存储条件

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GSK256073 (GSK 256073)

生物&药学活性

物理化学性质&存储条件

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