GSK2334470 | PDK1 inhibitor | Probechem Biochemicals

Chemical Structure : GSK2334470

CAS No.: 1227911-45-6

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GSK2334470 (GSK 2334470)

货号: PC-49261Not For Human Use, Lab Use Only.

GSK2334470 (GSK 2334470) is a potent, highly specific inhibitor of PDK1 with IC50 of 10 nM, does not inhibit 93 other protein kinases including 13 AGC-kinases most related to PDK1 at 5 uM.

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10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2380	In stock
100 mg		Get quote

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生物&药学活性

GSK2334470 (GSK 2334470) is a potent, highly specific inhibitor of PDK1 with IC50 of 10 nM, does not inhibit 93 other protein kinases including 13 AGC-kinases most related to PDK1 at 5 uM.
GSK2334470 ablated T-loop residue phosphorylation and activation of SGK isoforms and S6K1 induced by serum or IGF1 (insulin-like growth factor 1) in HEK-293, U87 or MEF (mouse embryonic fibroblast) cells, GSK2334470 also inhibited T-loop phosphorylation and activation of Akt.
GSK2334470 inhibited activation of an Akt1 mutant lacking the PH domain (pleckstrin homology domain) more potently than full-length Akt1.
GSK2334470 also suppressed T-loop phosphorylation and activation of RSK2 (p90 ribosomal S6 kinase 2), another PDK1 target activated by the ERK (extracellular-signal-regulated kinase) pathway.

物理化学性质&存储条件

分子量	462.602
分子式	C25H34N8O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide

参考文献

1. Najafov A, et al. Biochem J. 2011 Jan 15;433(2):357-69.

GSK2334470 (GSK 2334470)

生物&药学活性

物理化学性质&存储条件

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GSK2334470 (GSK 2334470)

生物&药学活性

物理化学性质&存储条件

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