GSK2193874 | TRPV4 inhibitor | Probechem Biochemicals

Chemical Structure : GSK2193874

CAS No.: 1336960-13-4

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GSK2193874 (GSK 2193874, GSK-2193874)

货号: PC-60294Not For Human Use, Lab Use Only.

GSK2193874 (GSK 2193874) is an orally active, potent, and selective blocker of TRPV4 channel with IC50 of 40 nM and 2 nM for hTRPV4 and rTRPV4, respectively.

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10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3680	In stock
100 mg		Get quote

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生物&药学活性

GSK2193874 (GSK 2193874) is an orally active, potent, and selective blocker of TRPV4 channel with IC50 of 40 nM and 2 nM for hTRPV4 and rTRPV4, respectively.
GSK2193874 shows high selectivity against TRPV1, TRPA1, TRPC3, TRPC6, TRPM8 (IC50>25 uM).
GSK2193874 is the first-in-class orally bioavailable TRPV4 inhibitor which demonstrates ability to improve pulmonary functions in a number of heart failure models.

物理化学性质&存储条件

分子量	691.62
分子式	C37H38BrF3N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(1,4'-bipiperidin-1'-ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

参考文献

1. Cheung M, et al. ACS Med Chem Lett. 2017 Mar 20;8(5):549-554.

2. Buday T, et al. Respir Physiol Neurobiol. 2017 Feb;236:1-4.

3. Thorneloe KS, et al. Sci Transl Med. 2012 Nov 7;4(159):159ra148.

GSK2193874 (GSK 2193874, GSK-2193874)

生物&药学活性

物理化学性质&存储条件

参考文献

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GSK2193874 (GSK 2193874, GSK-2193874)

生物&药学活性

物理化学性质&存储条件

参考文献

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