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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-GSK205 derivative 16-8
GSK205 derivative 16-8

Chemical Structure : GSK205 derivative 16-8

CAS No.: 1532515-60-8

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GSK205 derivative 16-8

货号: PC-62628Not For Human Use, Lab Use Only.

GSK205 derivative 16-8 is a specific small molecule dual-inhibitor of TRPV4 and TRPA1 with IC50 of 0.45 and 0.41 uM, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    GSK205 derivative 16-8 is a specific small molecule dual-inhibitor of TRPV4 and TRPA1 with IC50 of 0.45 and 0.41 uM, respectively.
    GSK205 derivative 16-8 displays no inhibitory potency toward TRPV1, TRPV2 and TRPV3.
    GSK205 derivative 16-8 effectively attenuates formalin-evoked trigeminal irritant pain in model of acute pancreatitis.

    物理化学性质&存储条件

    分子量 399.556
    分子式 C25H25N3S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(4-(2-(benzyl(methyl)amino)ethyl)phenyl)-4-phenylthiazol-2-amine

    参考文献

    1. Kanju P, et al. Sci Rep. 2016 Jun 1;6:26894.

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