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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-GSK205
GSK205

Chemical Structure : GSK205

CAS No.: 1263068-83-2

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GSK205 (GSK-205, GSK 205)

货号: PC-62627Not For Human Use, Lab Use Only.

GSK205 is a selective small molecule TRPV4 channel inhibitor with IC50 of 4.19 uM.

规格 价格 库存 数量
5 mg ￥1580 In stock
10 mg ￥2480 In stock
25 mg ￥4280 In stock
50 mg ￥7280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GSK205 is a selective small molecule TRPV4 channel inhibitor with IC50 of 4.19 uM.
GSK205 diminishes the chondrocytes' response to hypo-osmotic stress, reducing the fraction of Ca(2+) responsive cells, the regulatory volume decrease, and PGE(2) production in chondrocytes.
GSK205 attenuates the DEP-evoked Ca2+ response, reduces secreted MMP-1 in response to DEP in TRPV4 transfection in BEAS-2B cells.

物理化学性质&存储条件

分子量 481.46
分子式 C24H25BrN4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-(2-(Benzyl(methyl)amino)ethyl)phenyl)-5-(pyridin-3-yl)thiazol-2-amine hydrobromide

参考文献

1. Phan MN, et al. Arthritis Rheum. 2009 Oct;60(10):3028-37.

2. Kanju P, et al. Sci Rep. 2016 Jun 1;6:26894.

3. Li J, et al. Environ Health Perspect. 2011 Jun;119(6):784-93.

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