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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Kynurenine 3-Monooxygenase (KMO)-GSK180
GSK180

Chemical Structure : GSK180

CAS No.: 1799725-26-0

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GSK180 (GSK 180;GSK-180)

货号: PC-35240Not For Human Use, Lab Use Only.

GSK180 (GSK-180) is a potent and specific inhibitor of kynurenine-3-monooxygenase (KMO) with IC50 of 6 nM, shows negligible activity against other enzymes on the tryptophan pathway.

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25 mg ￥5850 In stock
100 mg ￥12800 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GSK180 (GSK-180) is a potent and specific inhibitor of kynurenine-3-monooxygenase (KMO) with IC50 of 6 nM, shows negligible activity against other enzymes on the tryptophan pathway; inhibits the convertion of kynurenine to 3-hydroxykynurenine with IC50 of 2.0 uM in cell-based assays; prevents multiple organ failure in rodent models of acute pancreatitis.

物理化学性质&存储条件

分子量 276.07
分子式 C10H7Cl2NO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(5,6-dichloro-2-oxo-1,3-benzoxazol-3-yl)propanoic acid

参考文献

1. Mole DJ, et al. Nat Med. 2016 Feb;22(2):202-9.

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