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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-GSK1702934A
GSK1702934A

Chemical Structure : GSK1702934A

CAS No.: 924377-85-5

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GSK1702934A (GSK-1702934A;GSK 1702934A)

货号: PC-35928Not For Human Use, Lab Use Only.

GSK1702934A (GSK-1702934A) is a potent and selective TRPC3/6 activator with EC50 of 80/440 nM, respectively.

规格 价格 库存 数量
10 mg ￥1880 In stock
25 mg ￥2980 In stock
50 mg ￥4880 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GSK1702934A (GSK-1702934A) is a potent and selective TRPC3/6 activator with EC50 of 80/440 nM, respectively.
GSK1702934A displays no significant activity against TRPV4, TRPA1, M1, M4, CaV1.2, hERG, NaV1.5, or CXCR5 receptors at 10 uM.
GSK1702934A induces TRPC3/6-currents in HEK293 cells transduced with recombinant human TRPC3/6, directly activates TRPC channels through by-passing phospholipase-C signaling.

物理化学性质&存储条件

分子量 395.521
分子式 C22H25N3O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(1-(5,6,7,8-Tetrahydro-4H-cyclohepta[b]thiophene-2-carbonyl)piperidin-4-yl)-1H-benzo[d]- imidazole-2(3H)-one

参考文献

1. Doleschal B, et al. Cardiovasc Res. 2015 Apr 1;106(1):163-73.

2. Sierra-Valdez F, et al. J Biol Chem. 2018 Oct 12;293(41):16102-16114.

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