Lanopepden (GSK1322322) | Peptide deformylase inhibitor

Chemical Structure : GSK1322322

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GSK1322322 (Lanopepden, GSK322)

货号: PC-70018Not For Human Use, Lab Use Only.

Lanopepden (GSK1322322) is a novel antibacterial agent that targets bacterial peptide deformylase (PDF), inhibits PDF activity and prevents bacterial protein synthesis.

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生物&药学活性

Lanopepden (GSK1322322) is a novel antibacterial agent that targets bacterial peptide deformylase (PDF), inhibits PDF activity and prevents bacterial protein synthesis.
Lanopepden (GSK1322322) demonstrates in vitro activity against MDR respiratory and skin infection pathogens, including MDR Streptococcus pneumoniae and MRSA.
Lanopepden (GSK1322322) inhibits S. pneumoniae ATCC 49619 with MIC of 0.12-0.5 ug/mL.

物理化学性质&存储条件

分子量	479.56
分子式	C22H34FN7O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((R)-2-(cyclopentylmethyl)-3-(2-(5-fluoro-6-((S)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl)-2-methylpyrimidin-4-yl)hydrazinyl)-3-oxopropyl)-N-hydroxyformamide

参考文献

1. Ross JE, et al. J Clin Microbiol. 2011 Nov;49(11):3928-30.

2. Arat S, et al. Antimicrob Agents Chemother. 2015 Feb;59(2):1182-92.

3. O'Dwyer K, et al. Antimicrob Agents Chemother. 2013 May;57(5):2333-42.

GSK1322322 (Lanopepden, GSK322)

生物&药学活性

物理化学性质&存储条件

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GSK1322322 (Lanopepden, GSK322)

生物&药学活性

物理化学性质&存储条件

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