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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HIV-GSK1264
GSK1264

Chemical Structure : GSK1264

CAS No.: 1392118-63-6

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GSK1264 (GSK-1264)

货号: PC-49515Not For Human Use, Lab Use Only.

GSK1264 is an allosteric inhibitor of HIV-1 integrase, disrupts the interaction between HIV-1 integrase (IN) and the cellular factor LEDGF/p75 with IC50 of 8.2 nM, inhibits HIV-1 replication with IC50 of 38 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    GSK1264 is an allosteric inhibitor of HIV-1 integrase, disrupts the interaction between HIV-1 integrase (IN) and the cellular factor LEDGF/p75 with IC50 of 8.2 nM, inhibits HIV-1 replication with IC50 of 38 nM.

    物理化学性质&存储条件

    分子量 453.51
    分子式 C26H28FNO5
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-2-(tert-butoxy)-2-(4-(8-fluoro-5-methylchroman-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl)acetic acid

    参考文献

    1. Gupta K, et al. J Biol Chem. 2014 Jul 25;289(30):20477-88.

    2. Gupta K, et al. PLoS Biol. 2016 Dec 9;14(12):e1002584.

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