GSK1070916 |CAS:942918-07-2 Probechem Biochemicals

Chemical Structure : GSK1070916

CAS No.: 942918-07-2

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GSK1070916 (GSK-1070916;GSK-1070916A)

货号: PC-45943Not For Human Use, Lab Use Only.

GSK1070916 is a potent, selective and ATP-competitive inhibitor of Aurora B and Aurora C with Ki of 0.38 nM and 1.5 nM, respectively.

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5 mg	￥880	In stock
10 mg	￥1380	In stock
25 mg	￥2180	In stock
50 mg	￥3680	In stock
100 mg		Get quote

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生物&药学活性

GSK1070916 is a potent, selective and ATP-competitive inhibitor of Aurora B and Aurora C with Ki of 0.38 nM and 1.5 nM, respectively.
GSK1070916 displays >250-fold selectivity over Aurora A; shows potent antiproliferative effect (EC50=7 nM) in A549 human lung cancer cells.
GSK1070916 causes inhibition of histone H3 phosphorylation at serine 10 in human colon cancer (Colo205) and tumor regression in human leukemia (HL-60) in mice.

物理化学性质&存储条件

分子量	507.6293
分子式	C30H33N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 26.5 mg/mL
Chemical Name/SMILES	Urea, N'-[4-[4-[2-[3-[(dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-1H-pyrazol-3-yl]phenyl]-N,N-dimethyl-

参考文献

1. Adams ND, et al. J Med Chem. 2010 May 27;53(10):3973-4001.

2. Hardwicke MA, et al. Mol Cancer Ther. 2009 Jul;8(7):1808-17.

3. Moy C, et al. J Transl Med. 2011 Jul 15;9:110.

GSK1070916 (GSK-1070916;GSK-1070916A)

生物&药学活性

物理化学性质&存储条件

参考文献

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GSK1070916 (GSK-1070916;GSK-1070916A)

生物&药学活性

物理化学性质&存储条件

参考文献

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