GSK1059615 |CAS:958852-01-2 Probechem Biochemicals

Chemical Structure : GSK1059615

CAS No.: 958852-01-2

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GSK1059615 (GSK 1059615;GSK-1059615)

货号: PC-42850Not For Human Use, Lab Use Only.

GSK1059615 is a highly potent, dual PI3K/mTOR inhibitor with IC50 of 0.4 nM/0.6 nM/2 nM/5 nM and 12 nM for PI3Kα/β/δ/γ and mTOR, respectively.

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10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

GSK1059615 is a highly potent, dual PI3K/mTOR inhibitor with IC50 of 0.4 nM/0.6 nM/2 nM/5 nM and 12 nM for PI3Kα/β/δ/γ and mTOR, respectively.
GSK1059615 inhibits survival and proliferation of established (SCC-9, SQ20B and A253 lines) and primary human HNSCC cells.
GSK1059615 blocks PI3K-AKT-mTOR activation in HNSCC cells, induces programmed necrosis but not apoptosis, suppresses SCC-9 tumor growth in nude mice.
GSK1059615 strongly reduces neutrophil-sperm interaction with IC50 of <10 nM in cattle.

物理化学性质&存储条件

分子量	333.3638
分子式	C18H11N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,4-Thiazolidinedione, 5-[[4-(4-pyridinyl)-6-quinolinyl]methylene]-, (5Z)-

参考文献

1. Carnero A. et al. Expert Opin Investig Drugs. 2009 Sep;18(9):1265-77.

2. Xie J, et al. Oncotarget. 2017 Feb 7;8(31):50814-50823.

3. Leontieva OV, et al. Aging (Albany NY). 2016 Dec 30;8(12):3535-3551.

4. Hong J, et al. Biol Reprod. 2017 Nov 1;97(5):671-687.

GSK1059615 (GSK 1059615;GSK-1059615)

生物&药学活性

物理化学性质&存储条件

参考文献

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GSK1059615 (GSK 1059615;GSK-1059615)

生物&药学活性

物理化学性质&存储条件

参考文献

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