GSK1016790A | TRPV4 agonist | Probechem Biochemicals

Chemical Structure : GSK1016790A

CAS No.: 942206-85-1

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GSK1016790A (GSK-1016790A, GSK 1016790A)

货号: PC-45654Not For Human Use, Lab Use Only.

GSK1016790A is a potent TRPV4 channel agonist, induces Ca2+ influx in HEK cells expressing human TRPV4 with EC50 of 2.1 nM.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
50 mg	￥3480	In stock
100 mg		Get quote

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生物&药学活性

GSK1016790A is a potent TRPV4 channel agonist, induces Ca2+ influx in HEK cells expressing human TRPV4 with EC50 of 2.1 nM.
GSK1016790A displays no effect on TRPM8 and TRPA1.
GSK1016790A evokes a dose-dependent activation of TRPV4 whole-cell currents at >1 nM, 300-fold more potent than 4alpha-PDD.
GSK1016790A induces urinary bladder contraction and hyperactivity in TRPV4+/+ mice.

物理化学性质&存储条件

分子量	655.613
分子式	C28H32Cl2N4O6S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 33 mg/mL
Chemical Name/SMILES	Benzo[b]thiophene-2-carboxamide, N-[(1S)-1-[[4-[(2S)-2-[[(2,4-dichlorophenyl)sulfonyl]amino]-3-hydroxy-1-oxopropyl]-1-piperazinyl]carbonyl]-3-methylbutyl]-

参考文献

1. Thorneloe KS, et al. J Pharmacol Exp Ther. 2008 Aug;326(2):432-42.

2. Rajasekhar P, et al. J Biol Chem. 2015 Nov 27;290(48):29051-62.

3. Hong Z, et al. Mol Neurobiol. 2016 Jan;53(1):759-768.

GSK1016790A (GSK-1016790A, GSK 1016790A)

生物&药学活性

物理化学性质&存储条件

参考文献

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GSK1016790A (GSK-1016790A, GSK 1016790A)

生物&药学活性

物理化学性质&存储条件

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